Antioxidant and Redox Regulation of Genes by Chandan K. Sen, Lester Packer, Patrick A. Baeuerle
By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle
This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in numerous sickness procedures. attainable ideas to pharmacologically and/or nutritionally manage such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox law of mobile responses* scientific implications of redox signaling and antioxidant treatment
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Extra info for Antioxidant and Redox Regulation of Genes
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Most were developed as hydrogen peroxide-resistant lines, but others include hyperbaric oxygen-, redox quinone-, and excitotoxinresistant lines as well. These lines were developed by long-term exposure to the oxidative stresses just mentioned followed by selection of cells exhibiting stress resistance. Because the stable lines developed resistance to oxidative stress, the logical explanation for their resistance was a change in the expression of antioxidant enzymes and related proteins. These lines have therefore been subsequently characterized with respect to the expression of these proteins and their corresponding mRNAs.