Antioxidant and Redox Regulation of Genes by Chandan K. Sen, Lester Packer, Patrick A. Baeuerle

Nutrition

By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle

This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in numerous sickness procedures. attainable ideas to pharmacologically and/or nutritionally manage such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox law of mobile responses* scientific implications of redox signaling and antioxidant treatment

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M. (1991). UVA (320-380 nm) radiation as an oxidative stress. In "Oxidative Stress: Oxidants and Antioxidants" (H. ), pp. 57-83. Academic Press, San Diego, CA. , and Osawa, T. (1999). Activation of stress signaling pathways by the end product of lipid peroxydation. 4-Hydroxy2-nonenal is a potent inducer of intracellular peroxide production. J. Biol. Chem. 274, 2234-2242. , and Kracht, M. (1996). Interleukin 1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase (ERK) in human glomerular mesangial cells.

Biol. Chem. 270, 7420-7426. , and Karin, M. (1996). Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274, 1194-1197. Rupec, R. , and Baeuerle, P. A. (1995). The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B. Eur. J. Biochem. 234, 632-640. Ryter, S. , and Tyrrell, R. M. (1998). Singlet molecular oxygen (~O2): A possible effector of eukaryotic gene expression.

Most were developed as hydrogen peroxide-resistant lines, but others include hyperbaric oxygen-, redox quinone-, and excitotoxinresistant lines as well. These lines were developed by long-term exposure to the oxidative stresses just mentioned followed by selection of cells exhibiting stress resistance. Because the stable lines developed resistance to oxidative stress, the logical explanation for their resistance was a change in the expression of antioxidant enzymes and related proteins. These lines have therefore been subsequently characterized with respect to the expression of these proteins and their corresponding mRNAs.

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