Antimetabolites in Biochemistry, Biology and Medicine. by J. Skoda, Peter Langen


By J. Skoda, Peter Langen

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Read Online or Download Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978 PDF

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Extra info for Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978

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5%, respectively, of that from dUMP; thus, competing reactions of these halogenated derivatives are sufficiently slow that they are not significant over the time of measurement and the reported numbers reflect true Κ · values. (6-12) The general scheme for these reactions is depicted in eq. CH -H folate + I ^ ± = * E-Ch^-H^folate-1 — 2 - + inactive enzyme 2 4 (2) where E-CH^-H^folate-I represents the initially formed reversible complex which undergoes unimolecular changes leading to inactivation.

Heidelberger, Biochemistry 13, 926 (1974). [13) Τ. I. Kalman and T. J . Bardos, Molec. Pharmacol. 6, 621 (1970). [14) B. R. Baker (1967) Design of Active-Site-Directed Enzyme Inhibitors, Wiley, New York, p. 114. [15) P. D. Ellis, R. B. Dunlap, A. L. Pollard, K. Seidman and A. D. Cardin, J . Am. Chem. Soc. 95, 4398 (1973). [16) Y. Yukawa, Y. Tsuno and M. Sawada, Bull. Chem. Soc. Jpn. 45, 1198 (1972). [17) L. Pauling and D. Pressman, J . Am. Chem. Soc. 67, 1003 (1945). [18) D. Agin, L. Hersh and D.

Equation 3 gave the log 1/K. 461 (3) highest correlation coefficient. The parenthesized values in this equation are the 95% confidence intervals; η represents the number of data points employed, r is the correlation coefficient, and s is the standard deviation. Variables not included in the equation were found insignificant in the correlation, and those used were noncollinear. This equation utilizes the Yukawa-Tsuno approach (16) by combining a resonance term (σ") with a pure inductive term ( y ) ; while σ" and are qualitatively analogous, the two vectors are not parallel.

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