Advances in Microbial Physiology, Vol. 46 by Robert K. Poole


By Robert K. Poole

First released in 1967, Advances in Microbial body structure is certainly one of educational Press's most famous and acclaimed sequence. The Editors have consistently striven to supply a various diversity of most fulfilling papers on all elements of microbial body structure. assurance of 'holistic' issues or entire mobilephone experiences reminiscent of ion fluxes, rigidity responses and motility have long gone hand-in-hand with particular biochemical analyses of person delivery platforms, electron shipping pathways and plenty of points of metabolism. Now edited through Professor Robert Poole, collage of Sheffield, Advances in Microbial body structure maintains to post topical and demanding experiences, studying body structure in its broadest context, to incorporate all fabric that contributes to our realizing of ways microorganisms and their part components paintings. In 1999, the Institute for medical info published figures displaying that the sequence has an influence issue of 5.35, with a part lifetime of eight years, putting it fifth within the hugely aggressive type of Microbiology; testimony to the excessive regard within which it really is held.

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VARIATIONS IN ANTIBODY RESPONSES AND ANTIBODY KINETICS A. Introduction During the early studies of HI and CF antibody responses to natural cases of YF, it became apparent that most immune responses could be classified into two patterns, primary and secondary infections (Theiler and Casals, 1958). This and other observations laid the foundation for serologic characterization of flaviviral infections. , wild versus vaccine strain), primary and secondary infections, or between sources of specimen, such as serum and CSF.

2000). , 1992). , 2000). J. , 1996). Although the exact cause is not entirely clear, the three most likely explanations are (i) a previously unrecognized exposure to a flavivirus with the subsequent disappearance of detectable antibody, (ii) broadening of antibody specificity, and (iii) an atypical immune response by the host. V. FLAVIVIRUS CROSS-REACTIVITY A. Introduction The complex combination of cross-reactivity of antibodies, including their temporal and qualitative changes, of immunogens (or antigens used in diagnostic tests), and of the sequence of viruses involved in sequential infections profoundly complicates the interpretation of serologic results.

2000), its application to etiologic agent identification is generally limited in flavivirus-endemic locations.

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