Advances in Applied Microbiology, Vol. 44 by Saul L. Neidleman

Biology

By Saul L. Neidleman

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Extra resources for Advances in Applied Microbiology, Vol. 44

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A more complex group containing the decalin-type motif, australiand australifunginol m), has been reported by Mandala fungin (107) and co-workers (1995) from fermentations of Sporomiella australis. " H 0 / .. (112) D (1ll)C STRUCTURES 109-112. medium containing cracked corn, ardamine, and inorganic salts, but, subsequent to the discovery of the activity, several liquid media were tested and one containing either mannitol or fructose, oat flour, fibco yeast, L-glutamic acid, and MES proved to support a four- to fivefold increase in metabolite.

1 pMwere obtained. , 1994a,b). E griseum produced fusidienol when cultured on a millet-based medium, and purified material was active against bovine and human enzyme, with IC5, values of 0 . 7 pM, respectively. ,, STRUCTURES 146,147. Supply is one of the inherent problems encountered while working towards bringing natural products to the clinic, and this is frequently the case with more exotic sources as well as with plant material. This is somewhat less of an issue with microbial fermentations since these are renewable, but they can never be ignored as a potential snag.

1 pMwere obtained. , 1994a,b). E griseum produced fusidienol when cultured on a millet-based medium, and purified material was active against bovine and human enzyme, with IC5, values of 0 . 7 pM, respectively. ,, STRUCTURES 146,147. Supply is one of the inherent problems encountered while working towards bringing natural products to the clinic, and this is frequently the case with more exotic sources as well as with plant material. This is somewhat less of an issue with microbial fermentations since these are renewable, but they can never be ignored as a potential snag.

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